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In a multinational study, 519 patients with newly diagnosed chronic-phase CML were randomly assigned to receive dasatinib at a dose of 100 mg once daily (259 patients) or imatinib at a dose of 400 mg once daily (260 patients).
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Of the 71 patients who lost CCyR, 24 (34%) remained on study and regained CCyR, 6 (8%) remained on study in MCyR and 41 (58%) discontinued study treatment.
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Debido a la mejora del resultado en los pacientes con características pronósticas favorables tratados con regímenes quimioterapéuticos contemporáneos y la falta de superioridad demostrable del TCMH en esta población de pacientes, en la actualidad se recomienda que este grupo de pacientes reciba un TCMH de un donante emparentado compatible solo después de la primera recaída y una segunda remisión completa (RC).
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